Scanty congenital plasmodium parasites as a possible cause for several autoimmune diseases
Identifieur interne : 002323 ( Main/Exploration ); précédent : 002322; suivant : 002324Scanty congenital plasmodium parasites as a possible cause for several autoimmune diseases
Auteurs : I. Yaffe [Israël]Source :
- Medical Hypotheses [ 0306-9877 ] ; 2001.
English descriptors
- Teeft :
- Acute malaria, Autoantibody, Autoimmune, Autoimmune disease, Autoimmune diseases, Autoimmune response, Blood stream, Blood transfusion recipients, Clin, Clin microbiol, Comprehensive explanation, Congenital malaria, Different plasmodium antigens, Endemic areas, Endemic regions, Erythrocytic cycle, Falciparum, Female ancestors, Greater risk, Harcourt publishers, Human host, Human malaria, Immunol, Internal medicine, Internal tissues, Latent merozoites, Lymph nodes, Lymphatic system, Malaria, Malaria infection, Malaria transmission, Mcgraw hill, Medical hypotheses, Merozoite, Multiple sclerosis, Parasite, Parasitemia, Peripheral blood, Persistent plasmodium parasites, Placental parasitemia, Plasmodium, Plasmodium falciparum, Plasmodium falciparum malaria, Plasmodium parasite, Plasmodium parasites, Pregnant women, Previous history, Rapid malaria tests, Rapid tests, Rheumatoid, Rheumatoid arthritis, Rheumatoid factor, Scanty amount, Scanty parasites, Systemic lupus erythematosus, Transplacental transmission, Tropical africa.
Abstract
Abstract: Recently it was reported that 19.8% of the patients with rheumatoid factor, who had no previous history of malaria and had not visited endemic regions for at least the past five years, generated false-positive results in two rapid malaria tests that capture two different plasmodium antigens. This intriguing finding supports the hypothesis presented, suggesting systemic lupus erythematosus and possibly several other autoimmune diseases are caused by a scanty amount of persistent plasmodium parasites in the internal tissues, which provokes diverse autoantibodies production, and can be transmitted congenitally. This hypothesis suggests a comprehensive explanation for the predominance of autoimmune diseases in African populations in the West yet their infrequency in tropical Africa, and for the studies reporting that several of these diseases benefit from antimalarials. The implication of this hypothesis is that these autoimmune diseases are actually infectious, and may infect individuals who contracted malaria in the past or whose female ancestors had contracted it, and possibly blood transfusion recipients.
Url:
DOI: 10.1054/mehy.2000.1151
Affiliations:
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Yaffe</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Haifa</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Hypotheses</title><title level="j" type="abbrev">YMEHY</title><idno type="ISSN">0306-9877</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="335">335</biblScope><biblScope unit="page" to="338">338</biblScope></imprint><idno type="ISSN">0306-9877</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-9877</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute malaria</term><term>Autoantibody</term><term>Autoimmune</term><term>Autoimmune disease</term><term>Autoimmune diseases</term><term>Autoimmune response</term><term>Blood stream</term><term>Blood transfusion recipients</term><term>Clin</term><term>Clin microbiol</term><term>Comprehensive explanation</term><term>Congenital malaria</term><term>Different plasmodium antigens</term><term>Endemic areas</term><term>Endemic regions</term><term>Erythrocytic cycle</term><term>Falciparum</term><term>Female ancestors</term><term>Greater risk</term><term>Harcourt publishers</term><term>Human host</term><term>Human malaria</term><term>Immunol</term><term>Internal medicine</term><term>Internal tissues</term><term>Latent merozoites</term><term>Lymph nodes</term><term>Lymphatic system</term><term>Malaria</term><term>Malaria infection</term><term>Malaria transmission</term><term>Mcgraw hill</term><term>Medical hypotheses</term><term>Merozoite</term><term>Multiple sclerosis</term><term>Parasite</term><term>Parasitemia</term><term>Peripheral blood</term><term>Persistent plasmodium parasites</term><term>Placental parasitemia</term><term>Plasmodium</term><term>Plasmodium falciparum</term><term>Plasmodium falciparum malaria</term><term>Plasmodium parasite</term><term>Plasmodium parasites</term><term>Pregnant women</term><term>Previous history</term><term>Rapid malaria tests</term><term>Rapid tests</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Rheumatoid factor</term><term>Scanty amount</term><term>Scanty parasites</term><term>Systemic lupus erythematosus</term><term>Transplacental transmission</term><term>Tropical africa</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Recently it was reported that 19.8% of the patients with rheumatoid factor, who had no previous history of malaria and had not visited endemic regions for at least the past five years, generated false-positive results in two rapid malaria tests that capture two different plasmodium antigens. This intriguing finding supports the hypothesis presented, suggesting systemic lupus erythematosus and possibly several other autoimmune diseases are caused by a scanty amount of persistent plasmodium parasites in the internal tissues, which provokes diverse autoantibodies production, and can be transmitted congenitally. This hypothesis suggests a comprehensive explanation for the predominance of autoimmune diseases in African populations in the West yet their infrequency in tropical Africa, and for the studies reporting that several of these diseases benefit from antimalarials. The implication of this hypothesis is that these autoimmune diseases are actually infectious, and may infect individuals who contracted malaria in the past or whose female ancestors had contracted it, and possibly blood transfusion recipients.</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Yaffe, I" sort="Yaffe, I" uniqKey="Yaffe I" first="I." last="Yaffe">I. Yaffe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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